All patients had complete blood cell count, renal and liver function tests, measurements of ESR, CRP, ANA, ENA, and anti-dsDNA antibodies, functional salivary gland scintigraphy, labial biopsy, and ophthalmologic assessment with Schirmer's test and tear film break-up time (BUT).
Finally, an additional 1,241 subjects were excluded for missing data on any of their liver function enzyme measurements and 2,003 individuals with any of the three liver function enzymes concentrations that we routinely check (ALT, GGT and AST) in whom these levels were found to be above the upper limit of normal according to our local laboratory.
The protocol includes twice-weekly blood tests and liver function tests; measurement of serum lactate levels, for early detection of lactic acidosis; a review of all medications taken by the patient, interrupting the use of those that may interact with linezolid; and periodic eye and neurological exams in patients set to receive linezolid for longer than four weeks.
Complete blood cell counts, including differential count, liver function tests, measurement of urea nitrogen, creatinine, and electrolyte levels, and urinalysis were performed weekly.
Liver function test (LFT) measurements were extracted from our local database and classified in 6 time points, every 24 h, from T0 (ICU admission) to T5 (H120).
CSA-treated patients presented a lower HEF value on hepatobiliary scintigraphy in spite of comparable liver function by traditional measurements indicating a decrease on HEF values by CSA.
Pretreatment evaluation consisted of a physical examination, full blood count, biochemical profile (renal and liver function tests), CA125 measurements and baseline staging CT.
Since endotoxemia frequently causes life-threatening inflammatory condition that involves multiple organ injury and dysfunction[16], we examined the effect of PAF administration on LPS-induced organ damages by measuring serum levels ALT and AST, which reveal liver function, and BUN, measurement of renal function.
Before surgery, each patient underwent conventional liver function testing and measurement of the indocyanine green retention rate at 15 min (ICGR15).
As in our study, liver enzyme and renal function measurements were more frequent than lipid measurements [ 11].
