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Liver function disturbances have been of concern in parenteral nutrition.
The toxicity of combined immunotherapy consisted of flu-like syndrome, fatigue, anorexia and transient liver function disturbances.
A majority also had transient liver function disturbances, mostly transaminase or alkaline phosphatase elevations (23 grade 1, 20 grade 2, 15 grade 3, 0 grade 4).
In addition, IL-2 was reduced in the second cycle because of grade 3 liver function disturbances (only enzyme elevations) in five patients and because of grade 3 creatinine elevation in one.
In 39 out of 74 (52.9%) patients, the IL2 dose was decreased to 2 MIU m−2 because of grade IV fever with (rapidly reversible) hypotension (n=17), severe fatigue (n=7) or grade 3 liver function disturbances (n=15).
Similar(54)
Apart from its beneficial effects, high dose of AG is associated with some adverse effects such as autoimmune symptoms, abnormal liver function, gastrointestinal disturbance, and flu-like symptoms [ 25, 26].
Moreover, liver function and electrolyte disturbances also have been observed in a significant percent of patients.
Aminoguanidine is reported to have side effects in patients in the high-dose arm of the study, which include flu-like symptoms, abnormalities in liver function test, gastrointestinal disturbances, rare vasculitis and anaemia (Freedman et al. 1999).
This is because the cholinesterase level may drop below normal when liver function is disturbed.
Sweating and anxiety may be evident, and disturbance in liver function has been recorded.
Persistent and relatively mild disturbance in liver function favors nonalcoholic fatty liver disease; transaminase flares are more compatible with glycogenic hepatopathy.
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