Suggestions(2)
Exact(1)
Oral tivantinib was found to have a manageable safety profile (based on prospectively defined liver function criteria) and preliminary antitumour activity in patients with HCC and Child-Pugh A or B liver cirrhosis (up to 7 points), and 360 mg BID was considered the RP2D in this patient population.
Similar(59)
We discuss how the hepatic circulation, microbiome, and nutrition affect liver function, and the criteria for considering cells derived from stem cells to be fully mature hepatocytes.
We speculated whether the generous inclusion criteria for liver function abnormality were responsible for the increased risk of neutropaenic fever.
It should be noted that the second dosing-to-first dosing analysis excluded subjects who did not receive or did not complete the second PA dosing due to the occurrence of liver function abnormalities fitting the nonredosing criteria.
Most large published series applied limited exclusion criteria regarding the liver function, often confined to a total bilirubin of <2 or <3 mg/dL [2, 16].
HCC patients with well-preserved liver function who meet with the Milan criteria have three potential curative therapeutic options: partial hepatectomy, local ablation, and liver transplantation.
Exclusion criteria also included abnormal liver function (in healthy subjects defined as outside the normal laboratory range; in the patient group defined as liver function tests > 3 times the upper limit of normal range).
Other exclusion criteria were persistent abnormal renal or liver function tests, persistent signs and symptoms of primary cardiovascular, respiratory or gastrointestinal disease.
Child-Pugh classification is the most commonly used criterion to evaluate the status of liver function.
Exclusion criteria were (i) acute hepatitis, (ii) elevated liver function test values or (iii) a history of nevirapine toxicity[ 23].
The severity of abnormal liver function was classified into grades 1 4 according to NCI Common Terminology Criteria for Adverse Events (CTCAE) 3.0.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com