Safety parameters, including vital signs, ECG measurements (recorded after 5 min rest before measurement of the clinic lung function tests), clinical chemistry and haematology, routine liver function assessments, and 24-h urinary cortisol (UC) excretion, were also assessed.
Safety endpoints included the incidence of adverse events (AEs) during the 24-week treatment period, 24-hour urinary cortisol (UC) excretion after 24 weeks of treatment, haematological and biochemical laboratory parameters, and routine liver function assessments.
Pretreatment evaluation included a detailed medical history and physical examination, a complete blood count, biochemical screening profile including liver function assessment and electrolytes, a prothrombin time and ECG.
A better liver function assessment, increased understanding of segmental liver anatomy, using more accurate imaging studies and the technical progress in surgery are the most important factors that have led to reduced mortality and morbidity of liver tumors [ 4].
Andersson, T. B. Evolution of novel 3D culture systems for studies of human liver function and assessments of the hepatotoxicity of drugs and drug candidates.
These regulatory mechanisms at the HBP level measured in vivo provide further evidence that 99mTc-NGA should have promise as a clinically useful receptor radiopharmaceutical for both quantification of liver function and assessment of liver morphology.
Consenting patients had full blood count, urea and electrolytes and liver function tests assessed before therapy along with baseline assessment of cardiac function by MUGA or echocardiogram.
One patient presented with raised liver function tests in multiple assessments after signing consent and therefore was deemed not suitable for study participation.
To assess inclusion and exclusion criteria, all subjects underwent a comprehensive clinical assessment which included a psychiatric evaluation by a board certified psychiatrist, structured diagnostic interview, medical history, vital signs, and laboratory assessments (liver function tests, complete blood count, and electrocardiogram).
In addition to and prior to the initiation of MDR/XDR-TB therapy, baseline investigations should be performed including height and weight, audiometry and visual acuity testing, thoracic imaging, ECG, full blood count, liver, renal and thyroid function assessments, serological tests for co-infections such as HIV and viral hepatitis B and C, and mycobacteriological investigations.
Static tests such as serum bilirubin, alanine aminotransferase, aspartate aminotransferase and the International Normalised Ratio INRR) are widely used for clinical routine assessment of liver function and in intensive care scoring systems.
