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The enhanced liver fibrosis test (ELF-test) has been validated for several hepatic diseases.
Recently, the combination of the enhanced liver fibrosis test and PNFI has proved relatively accurate for predicting liver fibrosis in children with NAFLD [ 6].
The enhanced liver fibrosis test includes a panel of serum markers that are extracellular matrix components, namely the tissue inhibitor of metalloproteinase-1, hyaluronic acid, and amino-terminal propeptide of type III collagen.
The enhanced liver fibrosis test (ELF test, Siemens) combines hyaluronic acid (HA), amino-terminal propeptide of type III collagen (PIIINP), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in an algorithm.
70, 85 (ii) Fibrosis biomarkers: The Original ELF (European Liver Fibrosis) test is a panel of automated immunoassays to detect three markers of matrix turnover in serum: hyaluronic acid (HA), tissue inhibitor of metalloproteinase 1 (TIMP1) and aminoterminal peptide of pro-collagen III (P3NP), used in combination with age.
The Enhanced Liver Fibrosis Test (ELF, Siemens Diagnostics) [ 9, 10] consists of an algorithm of three fibrosis markers (hyaluronic acid, amino-terminal propeptide of type III collagen, tissue inhibitor of matrix metaloproteinase 1).
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Over the last decade, great effort has been made to develop non-invasive liver fibrosis tests.
To evaluate the diagnostic accuracy of liver fibrosis tests and its influencing factors in a meta-analysis with individual data.
We aimed to evaluate STARD statements in the setting of diagnostic studies on non-invasive liver fibrosis tests, and to propose an extended version developed specifically for those studies.
Insulin resistance and liver fibrosis tests are also recommended for patients with a low likelihood of achieving SVR.
Multiple non-invasive tests based on serum protein glycomics have been developed for monitoring liver fibrosis (GlycoFibro test), detecting liver cirrhosis (GlycoCirrho test), and for screening HCC (GlycoHCC test).
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