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"The natural propensity for hematopoietic stem cells to repair the liver is poor," said Dr. Markus Grompe, a liver expert at the Oregon Health and Science University.
Dr. Irwin A. Arias, a liver expert at Tufts University, said that the work was "brilliant" but that any treatment was "a long, long way off".
"I believe that the reason is the extensive and recurring injury that the liver was exposed to in evolution: rotten food, plant toxins, viruses," says Markus Grompe, a liver expert at the Oregon Health and Science University.
Dr. Arias, the Tufts liver expert, interpreted Dr. DePinho's work more cautiously, saying it was too early even to be sure that short telomeres were the trigger for cirrhosis.
Reluctantly obliged to specialise, he became registrar to the great liver expert Sheila Sherlock and spent a year at Yale researching the neurology of diabetes for his MD thesis.
In this week's Scrubbing Up, Dr Nick Sheron, a liver expert at the University of Southampton, explains why we need a blood test to alert people to the harm they could be doing to their body.
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It is also working with liver experts, and it held a conference in February with them and the drug industry to develop better ways to identify potentially toxic drugs and spot problems once a drug is approved.
It pointed out that consultant hepatologists - liver experts - were present in only 28% of hospitals, while just 23% had dedicated alcohol-care teams to provide comprehensive support.
An independent panel of liver experts reviewed this case and considered Hy's law criteria were met.
Dr. Benhamou, a liver disease expert whose research has been widely published in medical journals, was also working at the time as a paid consultant to hedge funds and other investors, the authorities said.
Moore and his colleagues "have shown clearly that the receptor is important," says Steven Kliewer, a liver toxicity expert at the University of Texas Southwestern Medical Center in Dallas.
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