Precise and effective assessment of personality disorder is difficult, and the literature is fraught with research showing the difficulties in assessing personality disorders [ 10].
Which is to say, the task of the producer of any guide that seeks to discuss children's books or the history of children's literature is a fraught one.
"What is the impetus behind the work [is to] really to try and improve on the existing body of literature — which was fraught with methodological shortcomings — and get good quality evidence".
There has been a great deal of scholarship around the teaching and learning of evolution (Smith [2010a, b]; Sickel and Friedrichsen [2013]); however, the literature pertaining to evolution education is fraught with ambiguities regarding the effectiveness of courses containing evolutionary content toward increasing student acceptance of evolution.
The reason we chose to emphasise prognostic marker studies is that they represent a large proportion of the tumour marker literature and tend to be particularly fraught with problems because they are often conducted on retrospective collections of specimens, and analyses may contain substantial exploratory components.
Even in research settings that use structured interviews, differentiating bipolar from ADHD is fraught with controversy in the pediatric literature and the diagnosis of PBD can be unreliable [ 2], with some researchers suggesting that mood instability should be deemed a core feature of ADHD [ 52].
Research on reporting bias over the last decades has shown that trusting the published literature at face value, even peer-reviewed publications, can be fraught with difficulty a problem that spans drug classes.
This practice of dual marketing is quite common, but fraught with pitfalls and surprisingly neglected in the marketing literature.
However, even as the transformative possibilities of existential distress are reported in the literature [ 30], Yalom cautions not to be naive about how fraught with fear and anxiety the realization of mortality is.
An extensive literature accumulated in developed countries has demonstrated how each of these stages is fraught with difficulties and disappointments (Homel and Homel 2012; Ekblom 2012; Tilley 1993).
