The little mice carrying a naturally occurring missense mutation in the GHRH receptor (Ghrhr lit / lit ) have isolated GH deficiency (Eicher and Beamer, 1976; Godfrey et al., 1993).
In the Little (Ghrhr lit / lit ) mouse, lifespan extension is less substantial (23 25%), and only occurs when mice are provided a low fat diet [ 9].
Expression data was examined from four dwarf models that have previously been associated with significant lifespan extension in laboratory studies, including the Ames (Prop1 df / df ), Snell (Pit1 dw / dw ), Little (Ghrhr lit / lit ), and GHR-KO (GHR-KO) mutants.
Additionally, differential expression signatures associated with lowfat diet treatments were significantly similar to those of dwarf mutations (especially the Ghrhr lit / lit mutation) and multiple CR treatments (see Fig. 5).
This study presents a comparative analysis of microarray experiments that have measured hepatic gene expression levels in long-lived strains carrying one of four mutations (Prop1 df / df, Pit1 dw / dw, Ghrhr lit / lit, GHR-KO) and describes how the effects of these mutations relate to one another at the transcriptional level.
From lad lit to dad lit to bad lit, men have been barraged with an array of reading matter since Helen Fielding's Bridget Jones's Diary stormed up the bestseller lists and into our lives in 1997.
Oak Altar: No burners lit - 100% (Normal exp), One Burner Lit - 150%, Two Burners Lit - 200%.
Mahogany Altar: No burners lit - 150% (Normal exp), One Burner Lit - 200%, Two Burners Lit - 250%.
Gilded Altar: No burners lit - 250% (Normal exp), One Burner Lit - 300%, Two Burners Lit - 350%.
Marble Altar: No burners lit - 200% (Normal exp), One Burner Lit - 250%, Two Burners Lit - 300%.
