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The species-specific reactions and enzyme lists were retrieved from KEGG/XML and KEGG/PATHWAY.
Pathway gene lists were retrieved from the Molecular Signature Database formerly made for the GSEA tool [ 31, 37].
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Medication lists are retrieved from the electronic health record and patient updates are captured and reviewed by providers during the clinic session.
Two cancer gene lists, 'cancer gene census list' and 'CGP (cancer genome project) planned studies list' were retrieved from Wellcome Trust COSMIC (catalogue of somatic mutations in cancer) database and combined[ 22].
The RefSeq gene list was retrieved from the UCSC RefSeq database [ 63].
Then the cell cycle genes were deleted from this dataset (cell cycle gene list was retrieved from KEGG, Cell cycle database, and the original article).
The patient list and identifiers were retrieved from routine procedural records.
IC50 values for 11 mammalian cyclooxygenases, listed in Table 1, were retrieved from ChEMBL 16 [36].
In addition, the variables listed in Table 1 were retrieved from each study if available, checked for quality, recoded in a standardized manner and entered in the main database.
ASE genes lists for AlleleSeq and MBASED were retrieved from corresponding studies while for ASEQ we considered germline WES data available from the 1,000 Genomes Project collection and RNA-seq available from Rozowsky et al. study (see Additional file 1: Supplementary Methods).
Seventeen additional articles were retrieved from reference lists found in these papers and a general web search.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com