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The integration of significantly hypo- and hyper-methylated, over- and under-expressed, and gained and lost gene lists was performed using the VENN tool in PGS, and visualization to the resulting tracks was performed as previously described [39].

Global literature analysis of various gene lists was performed using BiblioSphere PathwayEdition (Genomatix Software GmbH, Munchen, Federal Republic of Germany) software which performs pathway and interaction analysis and labels genes which belong to certain known metabolic and signal transduction pathways.

Functional enrichment analysis of gene lists was performed using the DAVID webtool [ 53, 54].

Functional and anatomical analysis of the resulting lists was performed using DAVID Bioinformatics Resource 6.7 [ 87, 88].

Global literature analysis of various gene lists was performed using Pathway Studio 8.0 software (Ariadne Genomics, Inc., Rockville, MD).

Functional annotation of gene lists was performed using BRITE search from the Kyoto Encyclopedia of Genes and Genomes (KEGG) [ 35].

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Combinations of gene lists were performed using Gene List Venn Diagrams software [ 109] (Fig. 5).

Functional analyses of the resulting gene lists were performed using DAVID version 6.7 [ 67, 68].

GO and pathway analyses of gene lists were performed using David Bioinformatics software (http://david.abcc.ncifcrf.gov/) [ 50].

The functional annotations of the resulting gene lists were performed using DAVID.

The functional annotations of resulting gene lists were performed using the Gene Ontology and the KEGG databases.

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