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Table 5 lists pathways using the second method, based on the standard deviation between differentially expressed genes in a given pathway (Top differentially-affected pathways).
The difference in the amount of differentially expressed genes, distinctive gene expression patterns, specific regulated gene lists, pathways and unique gene networks, suggest a specific molecular mechanism for each compound.
Table 3 lists pathways that contain most differentially expressed genes when comparing MSCs and osteosarcoma.
GSMA and similar approaches will be useful for rapidly testing original as well as archived gene expression datasets for specific gene expression enrichment at the group level using either preset gene lists (pathways, promoter elements, disease association, etc) or empirically derived gene expression signatures [ 2].
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These listed pathways largely overlap those listed in Table 2.
If the input is a compound list, pathways associated with target compounds in KEGG database will be listed.
This opens the pathway browser in which either one of the listed pathways can be selected or a pathway search can be performed using a keyword.
Both application results (an integrative analysis of two data sets and an integrative analysis of three data sets) are presented for the listed pathways.
Given the smaller size of the immune response and interferon pathway gene lists, these pathways were not broken up into modules.
(For an extensive comparison and benchmarking, see the [22].) Note that SignaLink uses more than 20 reviews per each pathway to list pathway components, in contrast to the average 5 15 reviews per a pathway in other resources [22].
Tables listing pathway-based functional annotation statistics.
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