39 Importantly, a shorter time spent in LIS, anxiety and no recovery of speech production were found to be possible predictors of unhappiness.
For PCT no significant correlations (Spearman rank) were found to the lung injury score (LIS) (P = 0.93), the abbreviated injury scale (AIS-lung) (P = 0.33) and the sepsis-related organ failure assessment score (SOFA-lung) (P = 0.38).
A number of these proteins were found decreased in aged muscle, including vitamin D binding protein (GC, LIS-spot 1070), transthyretin (TTR, LIS-spot 2892) and apolipoprotein A-I (APOA1, LIS-spots 1847, 1855 and 3624).
We subsequently added two patients in whom TUBA1A mutations were found in clinical laboratories (one unexpectedly given the lack of LIS) and referred to us.
Also, no statistical differences were found for the number of ICU-free days and alive at day 28 and LIS at day seven and other secondary endpoints (Additional file 1: Appendix 2: Figure S1 and Appendix 4: Table S4).
However, communication between early adopters and late adopters in LIS education was found to be weak and not influential in the late adopters' decisions.
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A moderate correlation was found between LIS and lung weight/predicted body weight (PBW) (r = 0.56, P < 0.001).
Moderate statistical correlation was found between the LIS and GCS (correlation coefficient r = -0.51), and also between the LIS and GOS (r = 0.52), while the GCS and GOS were inversely related (r = -0.78).
Linear mixed model analysis showed that both CC16 and KL-6 were associated with the LIS over time but the strongest association was found with CC16.
