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However, there is no evidence that effervescent creatine, liquid creatine, and/or CEE promotes greater uptake of creatine to the muscle.
Moreover, changes in muscle creatine and phosphocreatine levels in response to CM supplementation were significantly greater than the liquid creatine and placebo groups.
These findings indicate that liquid creatine supplementation has no effect on muscle phosphagen levels and therefore may have no ergogenic value.
Some companies have even claimed that minimal amounts of liquid creatine would need to be ingested because of enhanced efficiency in transport through the blood and into the muscle.
This analysis allowed for a comparison of ingesting recommended doses of liquid creatine to a placebo, as well as seven times the amount recommended by the manufacturer that would purportedly provide an equal amount of CM.
Avoid liquid creatine.
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Subjects donated muscle biopsies prior to and following 5 days of supplementing their diet in a randomized and double-blind manner with either 5 mL of creatine liquid (purportedly providing 2.5 g of CM), 5 mL of a flavored placebo, 8 × 5 mL doses of creatine liquid (purportedly providing 20 g/day of CM), or 8 × 5 mL doses of a flavored placebo.
While other groups have been attempting to develop stable forms of liquid and/or gel forms of creatine with some success, there are no data available to date demonstrating that these types of creatine are absorbed more efficiently and/or have greater benefit compared to CM (Fig. 10).
Kreider et al. (2003b) carefully compared the effects of ingesting 20 g/day of CM to recommended doses (2.5 g/day of CM), as well as doses that would purportedly provide an equivalent amount of CM per day in liquid form (20 g/day) on muscle creatine, phosphocreatine, and total creatine levels.
In addition, while people may prefer the taste of liquid or gel versions of creatine, there is no evidence that these delivery forms provide a superior performance benefit.
The thought has been since CM is relatively insoluble that development of a liquid or suspended form of creatine may be more convenient to consume, be more readily absorbed into the blood stream, and promote a greater efficiency in transport of creatine to the muscle.
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