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Congenital lipoid adrenal hyperplasia is caused by a defect in a very early step in the steroid synthetic pathway that results in glucocorticoid and mineralocorticoid deficiency and failure of development of secondary sex characteristics.
This type of disease, known as lipoid pneumonia, occurs most frequently in workers exposed to large quantities of oily mist and in the elderly.
Patient SM, because of a rare condition called lipoid proteinosis, has holes where her amygdala would normally reside.
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