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The increase in lipid usage under fasting or food restriction is not only observed in mSOD1 mice, but in humans and non-mSOD1 models as well.
Thus, the sex difference observed in our study, with females having greater levels of lipid peroxidation than males, may be due to the increased lipid usage in female vs. male mSOD1 mice.
Mice with 20 weeks of rapamycin treatment had reduced adiposity and better lipid profiles with increased oxygen consumption (one of indicators of more lipid usage as fuel), and enhanced ketogenesis (a process that is involved in fatty acid breakdown and linked to modulation of aging).
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Better understanding of the mechanisms underlying fuel re-distribution may pave the way for new strategies to combat metabolic diseases, such as cardiovascular disease and diabetes type 2, in which a mismatch in regulation of lipid uptake and usage by tissues is an important feature (Klop et al., 2013; Young and Zechner, 2013).
These models adjusted for the study treatment, gender, age, baseline weight, duration of diabetes, usage of lipid-lowering drugs (for blood lipid profile), and baseline levels of each modeled component.
Up-regulated processes are DNA catabolism and lipid metabolism, indicating increased usage of lipids for energy metabolism.
These data indicate increased usage of lipid as an energy source, resulting in lower body weight.
Blood pressure, plasma lipid levels, and medication usage were obtained on annual examination using previously published methods (28).
Very limited production of nascent HDL particles at low mifepristone concentrations precluded usage of lipid mass analysis for determination of the large/small particle ratios.
Viral assembly and release takes place in close association to lipid droplets, probably by usage of the host's lipoprotein particle production pathway.
Recently, in a non-diabetic population, we showed that despite an increasing trend in general and abdominal obesity, a favorable trend in total cholesterol in both genders and TG in men occurred, which was not related to the increasing usage of lipid lowering drugs.
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