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According to memory models, people store semantic information in a complex network comprising conceptual nodes (external stimuli) and links (pathways between nodes) (McClelland 1988).
It potentially links pathways that signal through Rac1, RhoA and Cdc42 [ 56].
Both quantitative and qualitative studies that reported resilience and mental health outcomes among forcibly displaced persons (aged 18+) by way of exploring associations, links, pathways and causative mechanisms were included.
For example, pathway-based GWAS (Wang et al., 2010) maps SNP P-values to proximal genes and links pathways to diseases by testing whether any predefined pathways are enriched for genes that flank significant SNPs.
Primary quantitative and qualitative research studies that reported specifically on resilience and its impact on mental health of displaced persons by way of exploring associations, links, pathways and causative mechanisms were included to get a broader insight into how the relationships between resilience and mental health have been explored.
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WikiPathways links pathway components to over 50 supported biological databases, including Entrez Gene, Ensembl, Affymetrix, ZFIN, TAIR, and ChEBI.
Graph-based approaches are a killer app, so to speak, for anything that involves large networks with many nodes, and many linked pathways between those nodes.
Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.
Figure 3 shows the crosstalk of these significantly linked pathways.
In total 55 DEG featured in inflammatory linked pathways.
Several driving genes were identified for these linked pathways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com