The challenge to the distributed web services framework, was to provide an automatic and unique way of describing and linking the endpoint information in a formal way, able to be processed automatically by the software, with minimal human interaction.
Our first result states that we must always link the endpoints of any - path to each other.
If an endpoint event was registered in HDR only, we used the personal ID number along with the identity (i.e. side) of the operated knee (available in 47 of 313 cases) to link the endpoint to the latest index operation (supposing that complications requiring reoperation occur early rather than late).
5) Platforms that have the right elements can provide tremendous value by linking the IoT endpoints to the applications and analytics needed to generate business outcomes.
In practice, however, the pathophysiological processes linking the cause and the surrogate are manifold, as are the processes linking the surrogate endpoint and the true endpoint.
What is often lacking, though, is the ability to link these endpoints with biological relevant responses [59].
However, behavioral and physiological endpoints that link the organism and molecular level endpoints are scarce.
Various models that link the stressors to the biotic assessment endpoints, i.e., the IBIs, have been presented and discussed.
If relevant information is identified, and if there is an established link between the endpoint and an adverse population effect [ 88], this can then be used to refine the ERA assumptions as appropriate, and options for further risk refinement, risk management or further research can then be considered in the ERMP.
In an ideal world, the surrogate endpoint is mechanistically linked to the true endpoint via a single pathway and the surrogate endpoint is the result of a single pathophysiological process, which is affected by the intervention.
Modelling techniques usually extrapolate the available short-term evidence over time in order to estimate outcomes beyond the study period or to link intermediate endpoints to final outcomes.
