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GIs linking pathways from different clusters or involving unclustered pathways were recorded as uncharacterised.
Linking pathways by shared functionality enables us to examine the flow of information among biological functions, giving insight into the organisation of function within the cell.
Linking pathways by overlapping functionality revealed a modular network with energy metabolism forming a sparse centre, surrounded by several denser clusters comprised of regulatory and metabolic pathways.
In broad terms in the field of pharmacology, one sees frequent attempts to model events between vertical levels of integration, i.e., cells, tissues, and organisms, whereas systems biologists are often attempting to model events horizontally within the cell, linking pathways, and gene circuits.
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Graph-based approaches are a killer app, so to speak, for anything that involves large networks with many nodes, and many linked pathways between those nodes.
Figure 3 shows the crosstalk of these significantly linked pathways.
From this it is clear that the integration of these topologically linked pathways represent a true series of biochemical events linking the binding of the Wnt ligand, through activation of Daam1 to the actin polymerization machinery.
In total 55 DEG featured in inflammatory linked pathways.
Several driving genes were identified for these linked pathways.
These linked pathways correspond among other to immune response and metabolic pathways (glycolysis and gluconeogenesis).
Mutations within the EDNRB gene, or within other genes in linked pathways, may explain this observation.
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