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The sequence motif RXLGXGD in the GM-linker motif appears to be a key structural element supporting the observed large domain rearrangements within the SRP54 and linking binding of external ligands (GTP and signal sequence) by SRP to the acquisition of the proper NG-M configurations required for the targeting process.
Indeed, there have been very few studies directly linking binding to anaesthetic effects.
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The translocation pathway is critically dependent on ATP hydrolysis and drug interaction with P-gp is possible at one of a multitude of allosterically linked binding sites.
This windowing allows closely linked binding sites to be considered simultaneously.
This depends on direct association of Dorsal and bHLH proteins and cooperative binding to closely linked binding sites for the two respective proteins [34], [35].
Considered in toto, GATA2 binding was not associated with any particular expression trajectory during erythroid differentiation, but stratification by DNA motifs linked binding of GATA2 at GATA repeat/palindrome sequences to downregulation of gene expression.
A composite element contains two functionally linked binding sites for distinct transcription factors and in this way provides the basis for integrating the inputs of two signaling pathways and enabling specificity of expression [ 38].
While no concrete research has linked binding to breast cancer, they can create lumps which, while inherently benign, can lead to expensive, uncomfortable, and ultimately unnecessary testing.
In a previous study, this residue was predicted to be involved in linking nucleotide binding and peptide binding in protein kinases [ 68].
A clear inhibition was obtained, further linking the binding of C1q to CS-A with the binding of HAGG.
Our studies here reveal a potential cytokine cytokine interaction that participates in the assembly of the dodecamer complex, thus linking cytokine binding to receptor activation.
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