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The codon-based alignments of the domains/regions KRAB-A, KRAB-B, linker ("LINK") and zinc fingers ("ZNF") were done separately using ClustalW 1.83 [ 99].
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In this study, a series of catechol-based amides (8a n) with different amide linkers linking the catecholic moiety to the terminal phenyl ring was designed and synthesized as potent phosphodiesterase (PDE) 4D inhibitors.
This interaction is further stabilized when the cross-linker links up the monomer, finally a polymer is formed that has iron embedded inside.
For gene sets developed from Stanford 43k cDNA arrays, clone IDs were used as the "linker" to link the gene identifiers in the gene set to cDNA.
A molecular docking study allowed us to design a generic S0 binder, to which was attached a variable size linker, itself linked to an amino acid aimed to interact with the S1 site of PDZ domains.
HIV-1 protease tethered dimer used here contains a five residue linker, GGSSG, linking the N-terminus of second monomer to C-terminus of the first monomer [28].
We speculate that the primary motor function carrying cargos and the linker function linking an actin filament and a microtubule are two alternative functions of myosin-X.
The chemistry of using the UV-photocleavable linkers to link the pertinent components onto the surface of UCNPs is quite important for these applications.
The variable domains of T2.5 were fused via a peptide linker and linked at the construct's C-terminus to the myc epitope followed by the ER retention peptide to a scFv-fragment named αT2ib (Fig. 1A).
The principle behind the genetically encoded device for the detection of the viral protease activity is based on the proteolytic cleavage of the peptide linker, which links the orthogonal transcriptional activator Gal4-VP16 thethe membrane anchor.
The cleaved linker fragments cannot link the AuNPs together and the solution remains red.
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