Together with a server and printer(s), these computers are linked within a local network.
Strikingly, seven CIS genes, including four of the five CISs with the highest GKC p-values, were linked within a single network either directly or via nearest neighbours.
The identification of novel and biologically relevant candidate genes linked within a single expression network, the activity of which correlates with disease state and survival within the subgroup of tumours being modelled, illustrates the utility of this cross-species approach.
Strikingly, these candidate genes were enriched for transcription factors (p =2x10-5 =2x10-5ajoritheof which (6/7; Crebbp, majorityfia, Nfib, Tead1 and Tgif2) were linked within a single regulatofy netwhichenriched for genes associated with a differentiated neuronal phenotype.
Most of the likely transcriptional co-regulators (green molecules) that clustered with ΔNp63 were deemed to be linked within a ΔNp63 specific network, and importantly are involved in biological functions that include hair and skin development and function (p value: 5.46E-14 5.56E-6) (molecules with blue boundaries) (Fig. 4a, Additional file 10: Table S3).
If i and j are not linked within the network, the contribution to the SPF from this pair (i, j) equals zero.
Such specialization could modularize a molecular network by separating links within a network when duplicating a node.
Intriguingly, as some HH-EGFR cooperation response genes are linked within regulatory networks downstream of HH-EGFR cooperation, it will be important to evaluate the therapeutic efficacy of selected combinations of HH/GLI, EGFR and HH-EGFR response gene inhibitors in BCC and pancreatic cancer.
Theoretically, the largest moduli are expected when all of the potential cross-links within a polymeric network have reacted; therefore, if a cross-linking reaction is 100% efficient, then a cross-linking ratio of exactly 1 should yield the stiffest hydrogels.
In some instances (such as the social epidemiology of obesity) (Fowler and Christakis 2007) it has been shown that indirect connections (i.e. second degree links) within a social network may, under some conditions, exert a greater influence than direct interactions that however shape the global structure of the network.
