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Color perception problems, particularly involving the blue-yellow (tritan) mechanism, have also been linked with alterations in retinal dopamine: dopamine is a major neurotransmitter in the mammalian retina [ 41, 53].
These processes are important because diseases of the ovary including polycystic ovary syndrome (PCOS), premature ovarian insufficiency or ovarian failure, and ovarian cancer have all been linked with alterations in these fundamental cellular processes.
Calbindin 28-K null mice exhibit normal nervous system development and cerebellar histology, but these mice go on to develop impairments in motor performance linked with alterations in synaptic calcium currents (30).
Taken together, these data show that DNA methylation at specific CpGs differs according to fibrosis stage and we hypothesise that this may be linked with alterations in expression of genes known to regulate fibrosis progression.
A blunted vasodilator response to flow-mediated dilation implies a decrease in nitric oxide bioavailability, which may be evoked by different risk factors and pathological conditions that are linked with alterations of signaling pathways in endothelial cells.
Chronic psychological stress is linked with alterations in immune, inflammatory (Bierhaus et al. 2003; Steptoe et al. 2007), and endocrine function (Kiecolt-Glaser et al. 2002; Miller et al. 2002; Segerstrom and Miller 2004), including dysregulation of catecholamine production (Glaser and Kiecolt-Glaser 2005).
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Variation of the apparent activation energy has been linked with alteration of reaction rate determining steps.
The present study was designed to explore whether the neuroprotective effect of topiramate (TPM) was linked with the alterations of GABAergic signaling and astrocytes.
Estrogen concentrations decline precipitously and the ensuing hypoestrogenic state has been linked with substantial alterations in physical and psychological functioning.
The polymorphisms +190 C of HSPA1A, HSPA1B-179 C>T and HSPA1B 1267 A>G have been linked with significant alterations in the mRNA and protein expression [ 25, 26].
Exposure to the anti-androgenic fungicide vinclozolin, the estrogenic pesticide methoxychlor, or a mixture of plastic compounds during reprogramming of the germ line has been linked with epigenetic alterations that are inherited transgenerationally even in the absence of continued exposure [ 11- 15].
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