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Fergusson et al (1999) linked treatment rates with seeing a chest physician.
Previous studies performed among hypertensive patients have linked treatment satisfaction to numerous factors, which are recognised to be precursors to medication adherence.
For each biomarker there is a linked treatment that, prior to the trial starting, is thought likely to be effective on patients who test positive for the biomarker.
Schumacher and Holt (70) synthesized the literature on the prevalence of substance using women in the shelter system and reviewed different treatment approaches for addressing co-occurring IPV and substance use including sequential treatment, linked treatment, and integrated treatment interventions.
Lists of PDUs identified in each of the following 4 administrative data sources during that time period were obtained and linked: "treatment in the community," "arrest for possession," "probation," and "prison".
No data on age and gender were recorded in this database, since these were retrieved when the ITP linked treatment codes (conservative, PTA or surgery) in the Dutch insurance billing system to patients in each hospital's patient administration.
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A prior mean of around 1 gives a good balance of power to detect linked treatments and non-linked treatments.
The main advantage of the BAR approach is that it is not obvious how a group-sequential design would allow the linked treatments to be prioritised early in the trial whilst still allowing non-linked treatments to be allocated.
A higher prior mean (meaning patients are more likely to be allocated to linked treatments), results in the power to detect treatment effects between linked treatment biomarker pairs being higher than the parallel trials design.
Patients are randomised to control or linked treatments only throughout the trial.
If the linked treatments are effective, the allocation remains high; if ineffective, the allocation changes over the course of the trial to unlinked treatments that are more effective.
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CEO of Professional Science Editing for Scientists @ prosciediting.com