Sentence examples for linked to the variant from inspiring English sources

Checking control samples would be required to ensure that the variant is not a result of alternative splicing, but is actually causally linked to the variant of interest.

Single-nucleotide polymorphism frequencies are determined by: (1) the amount of time since the mutation occurred; (2) evolutionary pressure on biologically significant variants and those linked to the functional variant; (3) random genetic drift and (4) bottleneck events.

Several sites in and around OCA2 have been reported to be the functional variant or to be tightly linked to the functional variant leading to blue eyes.

Adult intelligence was similarly linked to the DNMT3L variant but this analysis was limited by the numbers studied and nature of the test and the association was not significant after Bonferroni correction.

Association mapping tests for an association between a set of genome-wide single-nucleotide polymorphisms (SNPs) and a specified phenotype, with the expectation that one or more of these SNPs may be linked to the causal variant(s).

Immune response defects, such as those linked to the PTPN22 variant (which associates with many autoimmune diseases), precede the clinical onset of the disease itself (see ref. 35 for a review on the evidence of such mechanisms in human autoimmune conditions).

However, one has to consider that the detected potential "functional" CNVs are not necessarily direct causal variants and might simply be linked to the causal variants.

The linkage disequilibrium between rs8099917 and the candidate causal variants was moderate (r ∼ 0.4; Fig. 4), whereas the other tag SNP, rs12979860, 8 was highly linked to the candidate variants (r ≥ 0.85, Fig. 4).

Vid21 is required for bulk histone H4 acetylation and is functionally linked to the histone H2A variant Htz1 and the Swr1 ATPase complex (SWR-C) that assembles Htz1 into chromatin [39].

We determined that deafness is genetically linked to the triallelic KIT variant, which quantifies the qualitative observation that all deaf cats carry at least one W allele. Distinguishing the two non- W alleles adds informativeness to the marker and hence increases statistical power.

Many GWAS hits were aggregated in this region for different autoimmune diseases, and here we tried to find out whether all the reported SNPs (six SNPs included) were linked to the same causal variant or whether they were derived from independent signals.