The acid carboxylic group was linked to the indole scaffold in position-3 via a methylene unit (compounds 4, 9, 10).
Compounds bearing a basic amine linked to the heterocyclic scaffold through a linear alkyl chain of varying length also afforded good ChE inhibitors.
Not all markers used in this study can be linked to the genomic scaffolds and not all scaffolds have been anchored onto the physical map, which needs to be resolved before answering these questions.
When the program analyzes which side chains can be linked to the seed scaffolds, we must also consider the possible sets of positions on the scaffold that can be linked by the side chains.
The method enables the generation of structurally diverse molecular hybrids including peptide, lipid, steroidal and sugar moieties linked to the 1,3,5-thiadiazine scaffold.
Interestingly, when a pyridinone pharmacophore was linked to the imidazo[1,2-a]pyridine scaffold, the geometric orientation of the link had a strong impact on the growth inhibition activity.
The success of these strategies are linked to the creation of scaffolds that are able to mimic the extracellular matrix architecture of the native meniscus.
A significantly higher amount of newly-formed bone was found with the strontium-free glass-ceramic scaffold, and possibly linked to the presence of akermanite at the scaffold surface.
We designed a straightforward biotinylated probe using the N-terminal substrate-like region of the inhibitory site of human cystatin C as a scaffold, linked to the thiol-specific reagent diazomethylketone group as a covalent warhead (i.e. Biot- PEG 2-Ahx-LeuValGly-DMK).
In S7.3, five STE3-like pheromone receptor genes were found, but only three pheromone genes are closely linked to the pheromone receptor genes in Scaffold 28 position 42257-66919.
