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FOXO4 alteration is closely linked to the progression of human cancer.
The association between DM and malignancy is well recognized, and the severity of DM symptoms has been linked to the progression of metastatic disease.
Malnutrition, inflammation, and oxidative stress are inter-related mechanisms linked to the progression of cardiovascular disease and prognosis of long-term hemodialysis (HD) patients.
Changes in vascular function, such as endothelial dysfunction are linked to the progression of heart failure (HF) and poorer outcomes, such as increased hospitalisations.
Excessive signaling by DDR1 and DDR2 has been linked to the progression of various human diseases, including fibrosis, atherosclerosis and cancer.
Perhaps, not surprisingly, deregulated activity of the NFκB pathway has been observed and linked to the progression of several human ailments, including cancers.
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This suggests that the UDG removal of incorporated uracil may directly link to the progression of the replication fork.
In view of the association with tumor stages (OTTHUMG00000002490) and regional nodal status (OTTHUMT00000048112) of oral tongue patients, we suggested that lncRNA expression could possibly link to the progression of tongue squamous cell carcinoma.
Proteolytic cleavage of E-cadherin has been linked to the malignant progression of adenocarcinomas, rapid changes in cell adhesion, signaling, apoptosis, and contributes to an invasive mesenchymal transformation [4], [5].
Aberrant protein O-GlcNAcylation is directly linked to the pathological progression of chronic diseases including diabetes, cancer, and neurodegenerative disorders.
Using a network biology approach, we aim to provide an example of how biomarker candidates speculated at the scientific literature could be mechanistically linked to the disease progression.
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