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Accordingly, this result suggests that the targeting action of O2– on Ras Cys, but not on Ras Cys, Cys, Cys, and Cys, is linked to the perturbation of the binding interaction between Cdc25 and wt Ras.
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The results for our initial design for the mechanism of drug combination synergy (Figure 1e) confirmed the proposed rationale: Gemcitabine serves as a drug establishing a baseline perturbation on the inter-module network, but Bortezomib could add a more focused perturbation on key gatekeeper modules which are linked to the checkpoint perturbation established by Gemcitabine (Figure 5d).
In general, the consideration of the general rearrangement of the entire expression network after a specific stimulus, with the consequent activation of functions not directly linked to the original perturbation, could be the basis for rationalizing the onset of unexpected side-effects after drug treatments.
Thus, the CypD-dependent mPTP is directly linked to the cellular and synaptic perturbations observed in the pathogenesis of AD.
Collectively, these quantitative measurements further support the findings of an elevated plasma level of α-hydroxybutyrate in LSFC patients, revealing an additional metabolic perturbation linked to the altered redox status in these patients.
These latter may be inaccurate to predict dynamic perturbations linked to the movement execution.
Thus, it can be suggested that regulation of the CTR under perturbation is linked to the activity of the photosynthetic electron transport chain.
Although new computational methods and mathematical tools are certainly needed, the major challenge in building such models is our limited understanding of how BN perturbations are linked to the KEs in the AOPs at a higher level of biological organization.
These structural perturbations are directly linked to the lipopeptide concentration.
In particular, EGR1 induces a number of gene products that have been linked to cellular perturbation, especially in the vasculature.
It also plays a critical role in the response to both acute and chronic vascular stress by inducing the expression of several gene products linked to cellular perturbation.
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