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Flux distribution is often controlled by multiple enzymes in the network [1] [10], indirectly linked to the pathways of interest.
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The Enzyme class was also directly linked to the Pathway class by parsing the KEGG [43] mapping files, thereby providing links to their potential roles in cellular processes.
With the discovery that ERK can be activated via the G protein and β-arrestin-dependent pathways, studies have revealed that the eventual cellular location of activated ERK is linked to the pathway mediating its activation.
Regarding termination, the screen identified among other factors an ubiquitin E3-Ligase so far not linked to the pathway.
The "closest" homologue was selected for each family, and insertions and deletions unique to nematodes were then linked to the pathway to which the best homologue could be assigned.
Similarly, we calculated the degree of every pathway node in the AP network, which was the number of ADRs that were linked to the pathway under investigation (see Figure 3(c)).
In different types of cancers, including CRC 20, 34, 35, hERG1 is functionally linked to the pathway that promotes the secretion of the VEGF-A, hence contributing to tumor angiogenesis 36.
In these tables the metabolites and genes of each pathway database are linked to the corresponding pathways.
Furthermore, genes acting in pathways directly linked to the polyamine pathway were differentially regulated.
Both apoptosis promoting and suppressing roles are displayed by the various DUBs linked to the apoptotic pathways.
Lys48- and Lys63-linked chains were recently linked to the Dsk2 pathway [ 42].
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