Exact(6)
The Enzyme class was also directly linked to the Pathway class by parsing the KEGG [43] mapping files, thereby providing links to their potential roles in cellular processes.
With the discovery that ERK can be activated via the G protein and β-arrestin-dependent pathways, studies have revealed that the eventual cellular location of activated ERK is linked to the pathway mediating its activation.
Regarding termination, the screen identified among other factors an ubiquitin E3-Ligase so far not linked to the pathway.
In different types of cancers, including CRC 20, 34, 35, hERG1 is functionally linked to the pathway that promotes the secretion of the VEGF-A, hence contributing to tumor angiogenesis 36.
The "closest" homologue was selected for each family, and insertions and deletions unique to nematodes were then linked to the pathway to which the best homologue could be assigned.
Similarly, we calculated the degree of every pathway node in the AP network, which was the number of ADRs that were linked to the pathway under investigation (see Figure 3(c)).
Similar(54)
Flux distribution is often controlled by multiple enzymes in the network [1] [10], indirectly linked to the pathways of interest.
Furthermore, genes acting in pathways directly linked to the polyamine pathway were differentially regulated.
Lys48- and Lys63-linked chains were recently linked to the Dsk2 pathway [ 42].
The TOR pathway may also be linked to the IIS pathway, as DAF-16 has been found to control the expression of daf-15 [ 140].
NMDA receptor signaling is linked to the FOXO pathway as well as to the ERK pathway [ 14].
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