The tendency for fatigue cracks to initiate in these grains appears to be strongly linked to the orientations of the grains relative to the direction of loading – grains less favourably aligned with respect to the loading direction appear more susceptible to fatigue crack initiation.
It was previously speculated that the Noonan syndrome-associated mutation N-ras-T50I might be linked to the orientation-switch III mechanism (Cirstea et al., 2010).
The identification of single nucleotide polymorphisms (SNPs) tightly linked to the genomic orientation of a given region should be useful to indirectly evaluate the genotypes of large genomic orientations in the individuals.
In an active state, a cofactor (phosphatidylinositol phosphate - PI5P) is linked to the polybasic region, which stabilizes the orientation of the Tudor domains, giving access to bind to modified histones (H3K9me3) [ 8].
She said: "The criterion at the heart of the restriction, that the couple should be married, is necessarily linked to the characteristic of an heterosexual orientation".
Marker Xgwm413 is the most tightly linked to the target gene but its orientation relative to the other two flanking markers was unknown.
The P300 has been shown to detect mindfulness effects in cognitive attention tasks such as the attentional-blink and the Stroop task with neutral stimuli (e.g., Moore et al., 2012; Slagter et al., 2007), indicating that the P300 may also prove a sensitive marker for changes to affective orientation linked to the efficiency of attention processing.
The strong correlation between the crystallographic boundary planes and the grain orientation shows that the boundary orientation is closely linked to the active slip systems.
Interestingly, when a pyridinone pharmacophore was linked to the imidazo[1,2-a]pyridine scaffold, the geometric orientation of the link had a strong impact on the growth inhibition activity.
Thus, spindle orientation is linked to the proliferation, fate and survival of aNPs.
These data support the idea that MT orientation is strongly linked to the morphological changes required for muscle differentiation.
