Sentence examples for linked to the mutant from inspiring English sources

When we decoupled the WT and mutant miR-122-binding sites from the virus, and placed them downstream of luciferase to study their effect on target regulation, we observed that the reporter linked to the mutant sequence was more suppressed when miR-122 was inhibited.

From the above experiments on brain mRNA from SAP102 and PSD-95 mutants it seems likely that these effects of genes linked to the mutant allele might be generally important in other knockout lines and other tissues.

MV-sensitive individuals that arose from the same backcross segregated for the presence of the T-DNA in a ratio of 68∶30, close to an expected 2∶1 ratio (χ2 = 0.33, P>0.05), indicating that oxt6 contained a single T-DNA insertion that was very likely linked to the mutant phenotype.

Thus, target proteins remain covalently linked to the mutant oxidoreductase and become amenable to isolation and analysis (principle shown in Figure 1A).

This resulted from FVB/n alleles of genes linked to the mutant Smchd1MommeD1 allele being retained in the backcross to C57Bl/6 J.

Markers that are not linked to the mutant will show no difference in the wild-type and mutant pools, while linked markers will show an overrepresentation of the mutant parent allele only in the mutant pool.

The article is then scanned for mutants, which in turn are linked to the relevant mutant records in GPCRDB.

We use a structured-coalescent approach to model the effect of directional selection on the gene genealogies of neutral markers linked to the selected mutant.

We favor a model where selective killing by some current therapies is specifically linked to the CIN mutant genetic background of the tumor and not only to the tumor-associated hyperproliferative phenotype.

To evaluate in maternal plasma, the efficacy of detecting the paternal β-gene mutation and informative single nucleotide polymorphisms (SNPs) linked to the paternal-mutant or -normal allele in non-invasive prenatal diagnosis (NIPND).

Increased genes in the Nes-Cre Wt1co/co kidneys were uniquely involved in nephron development, kidney size and positive regulation of epithelial-to-mesenchymal transition (EMT), whereas phenotypes uniquely linked to the Pax8+/Cre Wt1co/co mutants include glomerular crescent and abnormal glomerular capillary morphology.