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All these cellular processes have been linked to the longevity effects of TOR disruption in multiple species.
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Several of the mechanisms implicated in the induction of senescence by p53 have also been linked to the regulation of longevity.
QTLs are mapped by linkage to the molecular markers and if there is a significant statistical difference in longevity between genotype classes for a particular marker, one infers a QTL affecting longevity that is linked to the marker.
The reduced detrimental effect of the LCHF diet on longevity is very strongly linked to the differential effect of the two high-fat diets on adiposity development.
In many cancer cells TERRA is downregulated, providing a possible link to the longevity of cancer cells by telomerase-mediated lengthening of chromosomal ends (Ng et al, 2009; Figure 1C).
In addition, recent genetic studies on long-lived humans have shown that single nucleotide polymorphisms (SNPs) in the FoxO3 gene, one of the four human FoxO family members, are closely linked to extreme longevity and the reduction in age-related diseases [ 8- 12].
We proposed that mutation rate variations are possibly linked to species longevity through the action of natural selection: too high a mutation rate would be deleterious in long-lived mammals because it could result in premature aging due to the accumulation of somatic mtDNA mutations [ 14], see also [ 15- 17].
It has been suggested that both generation time (which is linked to longevity) and the rate of apical growth (which is linked with the rate of mitosis) are negatively related to DNA substitution rate in plants [ 20].
"Eudaemonic and hedonic aspects of well-being had previously been linked to longevity, so the possibility of finding beneficial effects seemed plausible," Fredrickson told me.
Diet has often been linked to longevity: reducing the calorie intake can influence aging.
Second, DNA variants in the FOXO3A gene have been linked to exceptional longevity in at least eight studies across the world.
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