Sentence examples for linked to the lifespan from inspiring English sources

ISC proliferation in the intestine is linked to the lifespan of the whole organism [ 14].

With no user access, the lifespan of the mobile device become inextricably (literally) linked to the overall lifespan of the battery.

An alternative model proposes that cancer development is rate-limited by the dynamics of age-dependent tissue fitness decline (and is thus tightly linked to the evolution of lifespan and aging), whereby cells in aged tissues of lower general fitness provide more room for positive selection for oncogenic events that have accumulated in tissues over a lifetime [ 23, 24, 34].

In agreement with evolutionary models of aging, our results suggest that cancer is not rate-limited by the occurrence of oncogenic mutations as postulated by the current model of carcinogenesis, but its incidence instead is tightly linked to the evolution of lifespan and is promoted by altered selective value of oncogenic mutations that accumulate over lifetime in aged tissues.

Reduced IGF signaling was recently shown to be linked to the regulation of human lifespan (Suh et al., 2008; Willcox et al., 2008; Flachsbart et al., 2009), suggesting that the longevity functions of this pathway are conserved from worms to humans.

The analysis of other fecundity related traits (number of clutches, average clutch size, data not shown) indicates that this lower fecundity is essentially due to a reduction of the clutch number, which is probably linked to the reduction of their lifespan.

But it is tempting to speculate that the shortening of the lifespan is linked to the reported crucial role of microcephalin/BRIT1 in DNA damage response [33], [35].

Among the genes showing the largest and most statistically significant CR-induced expression differences are Ddit4, a key regulator of the TOR pathway, and Nnmt, a regulator of lifespan linked to the sirtuin pathway.

To test whether the lifespan extension was linked to the paralysis phenotype, we grouped populations of C. elegans with either mild or severe muscle cytoskeleton detachment in early adulthood (Fig. 5E,F) and then carried out lifespan analysis.

Many studies have also demonstrated that increasing the autophagic capacity by pharmacological or genetical manipulations can prevent the pathology linked to the aging process and even extend lifespan [ 78- 80].

Although considerable data have demonstrated that suppression of the insulin/IGF-1 and mTOR signaling pathways are linked to lifespan extension, the underlying mechanisms remain elusive.