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In contrast, desmosomes form strong adhesions that are linked to the intermediate filament system and are essential for tissue integrity [10], [11].
In the desmosomal plaque the cytoplasmic domains of the desmosomal cadherins are linked to the intermediate filaments by the armadillo proteins plakoglobin (Pg, also known as γ-catenin) and plakophilins (PP) as well as the plakin family protein desmoplakin (Dp) [3] [5].
Thus, the results of this study suggest that the GRM7 rs37952452 polymorphism could be more closely linked to the intermediate phenotype of selective attention deficits than to the behavioral phenotype or the disease itself.
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The CE is subsequently linked to the keratin intermediate filament network and, through the actions of TGase-1, to components of the lamellar lipid matrix.
Following the applied study framework, one group of key findings linked to the content, process, context, and intermediate outcomes of the programme are discussed.
These latter measures will provide data on the efficacy of the intervention on intermediate endpoints linked to the primary outcome of interest.
If they remain linked to the same handles, then each handle would ultimately be linked to a diverse set of different intermediates of metabolism.
These catabolic pathways link to the glycolytic pathway, and intermediates could take part in the tricarboxylic acid cycle.
Two of them, Nesprin1 and 2, are large actin-binding proteins [15], [20], whereas Nesprin3, a smaller molecule, binds to plectin that in turn links to the intermediate filament system and/or actin [18], [21].
Based on these observations, the present study tested the hypothesis that nestin expression in vascular smooth muscle cells (VSMCs) of the adult rat carotid artery and aorta was directly linked to proliferation and the intermediate filament protein was downregulated during the early stage of experimental type I diabetes attributed to hyperglycaemia.
The desmosomal cadherins are linked to intermediate filaments of plaque proteins (desmoplakin, plakoglobin and plakophillin) in the cytoplasm [ 7].
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