Despite these encouraging results, there are drawbacks in currently available data that these markers are not necessarily patho-physiologically linked to the development of the OF and therefore, elevation of these markers simply reflects ongoing OF.
In spite of many advantages (e.g. cost, parametric studies possibilities), these tools still have drawbacks linked to the representativeness of material and geometrical non-linear behaviours and to mesh sensitivity.
Among renewables, solar energy instead has the major drawback of not being continuous because inevitably linked to the availability of irradiation unless to provide too much expensive storage.
Despite these advantages, FTIR microspectroscopy also bears several drawbacks, some of which are directly linked to the physical nature of the technique.
Nevertheless, the drawback linked to the PCR complicates the setting of a unique multiplex assay targeting simultaneously all GM events.
The main drawback of such process is closely linked to the high temperature required to reach a sustainable propane conversion that affects catalyst stability owing to coke formation on the catalyst surface.
The major drawbacks of these serological methods are linked to the antibodies that remain detectable after a cure and those that are due to past or present asymptomatic infection present in a sizeable proportion of residents of endemic areas.
A leaky RyR2 could possibly be linked to all major drawbacks of heart failure: impaired systolic force generation, compromised passive diastolic relaxation and a disposition for arrhythmias.
"Geographic" isolation of the gynecologic consulting rooms, according to the physicians, is linked to several drawbacks.
The drawbacks linked to its employment in regenerative medicine arise from its hydrophobic nature and the lack of biochemical signals linked to it.
However the issues to control their delivery into the interest areas of the brain and their surgical administration linked to their unability to cross the blood brain barrier are many drawbacks responsible of undesirable side effects limiting their clinical use.
