These genes are included in the mGlu group III receptors that are linked to the inhibition of cyclic AMP cascade.
The PAS domain has been linked to a variety of (small) signaling molecules [ 85] and the same holds for the GAF domain (see [ 38]), although it was originally linked to the recognition of cyclic nucleotides (see [ 86]).
DSF signaling is tightly linked to the intracellular second messenger cyclic dimeric GMP (c-di-GMP) [ 101, 102].
They have been linked to the photosynthetic linear and cyclic electron transport chain (Price et al., 2008; Maeda et al., 2002; Shibata et al., 2001).
GAF domains (cyclic GMP, adenylyl cyclases, FhlA) are linked to the binding of small-molecules, in particular the second messengers cyclic AMP (cAMP) and cGMP [ 35].
Air-stable P,N-bidentate ligands L1 L7 with cyclic secondary amine moieties linked to the benzene rings of triphenylphosphine were designed and prepared.
The GAF domain family, linked to the binding of second messengers, is involved in cyclic nucleotide signaling, transcription, phototransduction, and probably many more unidentified processes [ 58].
Another factor which could be of importance is cyclic variation in thresholds to pain stimulations linked to the menstrual cycle [ 32].
Last week's report that the current "pause" in global warming could be linked to cyclic cooling in the Pacific will be interpreted by climate sceptics as evidence that global warming isn't happening, and by politicians as a reason to forget about climate change and carry on with business as usual.
We found recently that GLP-1 restored the impairment of glucose-stimulated insulin release in islets taken from lipid-infused rats and that this effect was linked to increased cyclic AMP levels and suppression of islet activities of both ncNOS and iNOS [3].
Group II and group III mGluRs are linked to inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
