Sentence examples for linked to the checkpoint from inspiring English sources

The results for our initial design for the mechanism of drug combination synergy (Figure 1e) confirmed the proposed rationale: Gemcitabine serves as a drug establishing a baseline perturbation on the inter-module network, but Bortezomib could add a more focused perturbation on key gatekeeper modules which are linked to the checkpoint perturbation established by Gemcitabine (Figure 5d).

It was recently reported that human SMG-1 is functionally linked to the tumor suppressor checkpoint protein p53.

It has been shown that the E6 and E7 proteins of HR-HPV types disrupt cell cycle checkpoints, particularly affecting CDKI linked to the G1- and G2-checkpoints with consequent accumulation of genetic aberrations [ 19].

HPV 16 E6 and E7 disrupt cell-cycle checkpoints, particularly affecting by different mechanisms nearly all CDK inhibitors linked to the G1 and G2 checkpoints (Galloway and McDougall, 1996).

Hepatic apoptosis was, however, unchanged, and the authors suggested that downregulation of the cell cycle checkpoints may be linked to the recent finding that inhibition of checkpoint function increases stress resistance and lifespan in C. elegans (Olsen et al 2006).

The remaining template for lagging strand replication is coated by RPA and thus recruits sensors linked to the ATR-mediated DNA damage checkpoint.

In addition, the proteasome-related activity of BRCA1 appears to be tightly linked to the RB1-mediated cell cycle checkpoints.

The ability of HPV oncoproteins to disrupt growth regulatory proteins may have effects on the cyclin-dependent kinase (CDK) inhibitors linked to the G1- and G2- checkpoints.

Regulated by AKT and a key player in the AKT/PI3K/mTOR pathway, glycogen synthase kinase 3 beta (GSK-3), the critical checkpoint for glycogen synthesis, is linked to the circadian rhythm [ 33].

The protein product of this gene has been linked to the nuclear import of a protein important for DNA repair and checkpoint function [104], [114].

Indeed, I think that the logic behind the DNA replication checkpoint-dependent inhibition of recombinational repair is linked to the fact that the repair occurs at HR centers.