In general, protein biomarkers are most useful if their functions are known and thus can be mechanically linked to the molecular basis of adverse health effects.
This remarkable story not only shows how a clinical diagnosis can successfully be linked to the genetic basis for a COPD phenotype, it also highlights the long time span required in the past to go from clinical observation (1963) to identification of the amino acid substitution (1978) with limited tools.
The database was linked to the cohort on the basis of birth date, sex, postal code, and general practitioner with a validated probabilistic method (30).
The PRAME expression data were linked to the clinical database on the basis of the Rosetta Bioinformatics patient identification number (rosid).
The objective of the study was to assess whether the cluster of human Q-fever cases in this urban area could be linked to the suspected source on the basis of the distribution of illness onset and residence location relative to small ruminant farms.
While gSNP markers were not used in the construction of the YI linkage map, those that appeared to be linked to the ms1 gene on the basis of the segregation patterns observed in 17 male-infertile TO-S progeny were also used in the construction of the partial map.
To introgress the wild favourable allele into cultivated tomato, marker-assisted selection plays an important role and the map positions and markers linked to the QTLs provide a basis for breeders to design optimal breeding strategies.
These statistical relationships could be linked to the hypotheses we formulated on the basis of the literature or theoretical considerations.
As an example, in a 3M-6M baswapswap linked to the LIBOR, the 3-month LIBOR is paid quarterly and the 6-month LIBOR is received semiannually.
While population genomic data support the idea that the observed transcriptomic differences have a genetic basis tightly linked to the corresponding genes, we sought additional evidence bearing on this question.
The temperature-sensitivity difference is due to a polymorphism in the rmp1 gene, which is tightly linked to the mating type, while the genetic basis of the difference in aging, also highly-linked to the mating type, is unknown.
