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Although allergy is linked to sensitization, children may be allergic but not sensitized, as well as sensitized but not allergic (Table 1).
The arthritic animals displayed a biphasic febrile response that was previously shown to reflect inflammation linked to sensitization and immune arthritis, respectively, and to follow the systemic release of pro-inflammatory cytokines [ 32].
While the functional role of gp130 expressed on neurons is not well understood, this protein has been linked to sensitization of pain-sensing nerves through activation of phosphoinositide 3-kinase, protein kinase C-delta and Janus kinase/signal transducer and activator of transcription 3 signaling pathways and through regulation of the pain-activated ion channel TRPV1 [ 2, 3].
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Behavioral assays involving NO performed in this study are linked to peripheral sensitization: in one, NO donor causes thermal sensitization (Fig. 6A); in the other, sensitization reveals a nociceptive role for NO donors (Fig. 6B, C).
The LLNA results indicate that MMA has low sensitizing potency, substantially less than that of agents linked to respiratory sensitization.
Asthma is an environmentally triggered disease that is linked to allergic sensitization in approximately 40 to 60% of cases [ 1].
Allergen exposure in early life has been linked to allergic sensitization and later asthma, but there is little evidence for an association between early allergen exposure and wheezing in infants or children under 5 years of age (Sporik et al. 1990; Brussee et al. 2005).
On the molecular level, our and recent data [9] clearly indicate that the risk for adverse reactions upon ingestion of cooked eggs is linked to Gal d 1 sensitization.
The separate analyses of mechanical pain sensitivity in the two groups of subjects give the opportunity to detect whether a substance is linked to presence of peripheral sensitization in TM.
These findings suggest that early life adversity is linked to enhanced central and peripheral sensitization in young adults.
While our study adopted the approach used in previous studies that modeled the impact of respiratory sequelae, we used two additional sources [29, 36] to model asthma and allergic sensitization sequelae, linked to MA-RSV.
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