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Indeed, various recent studies suggest that pathway activation can be linked to sensitivity to drugs targeting downstream components.
A "defensive behavior syndrome" could be postulated, in which a correlated suite of defensive traits could be linked to sensitivity to electric shock.
For example, EGFR mutations predictive of response to erlotinib and gefitinib were identified at the expected frequency (12%) in non-small cell lung cancer, and KIT mutations linked to sensitivity to imatinib and nilotinib were detected in 76% of GISTs.
c-erbB-2 expression/activity has been linked to sensitivity against CDDP.
Heterodimerization of IGF-1R and insulin receptor (IR) has been linked to sensitivity to anti-IGF-1R antibodies [ 22].
In addition, the presence of IGR-1R and IR-β heterodimers in hepatic and gastric cell lines has been linked to sensitivity to anti-IGF-1R antibodies [ 22].
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Accumulated evidence recently have shown that normal miRNA expression is closely linked to the sensitivity of cancer cells to anticancer drugs by targeting chemo-sensitivity-related genes (Wu and Xiao, 2009; Ren et al, 2010).
In acinar cells, IP3R2 expression levels have been linked to the sensitivity toward metabolic stress, as IP3R2 is the most sensitive toward ATP regulation and determines the influence of ATP depletion on intracellular Ca2+ signaling.
That makes sense, since insomnia has been linked to higher sensitivity to pain.
The overexpression of TSPYL5 has also been linked to chemotherapy sensitivity in both lung and prostate cancer cells20,61.
The uncertainty is derived from asymptotic statistics and it is shown to be closely linked to the sensitivity of the experiment to the parameters.
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