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Phylogenetic profiling confirms what was also noted in previous studies, namely that the functionality of protein families with a larger gene copy number in extant pathogens is linked to pathogenicity.
These studies establish that optical-based Raman diagnostic methods are able to sensitively and accurately detect influenza virus RNA mutations linked to pathogenicity in emerging highly pathogenic avian and pandemic influenza viruses without amplification or labeling.
Metabolic circuits linked to pathogenicity: A metabolic gene circuit whose genes are commonly found in pathogenic strains is the CMP-Pse metabolism circuit cluster belonging to the amino nucleotide sugar mechanism.
These results provide a foundation for subsequent genomewide association studies to identify genes and genotypes linked to pathogenicity in humans.
Furthermore, the analysis of TpLRRs suggested that genes linked to pathogenicity can be shared between parasitic bacteria and parasitic eukaryotes [23].
The orthologs linked to pathogenicity in these circuits are shaded in pink.
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This phenomenon is intimately linked to pathogens of animals or plants and their pathogenicity [ 1, 2].
In summary, genome analysis shows that M. suis is dependent on host cell metabolism and this characteristic is likely to be linked to its pathogenicity.
Further studies of MoVam7, MoSec22, and additional members of the SNARE complex are likely to reveal critical mechanisms in vacuole formation and membrane trafficking that is linked to fungal pathogenicity.
Overall, M. suis has a typical Mollicutes genome and is dependent on host cell metabolism for its survival (hemotrophic not just hemotropic), a characteristic that is likely to be linked to its pathogenicity.
Our data suggest that this factor could either be directly implicated in the pathogenesis of PLA, or linked to another pathogenicity factor on the 185 kb plasmid that harbors gene cf29A [75].
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