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This overgrowth probably is not linked to major changes in the source niches (nose and throat), yet pathogens may originate from there.
The high mouse virulence of all strains tested suggests that signature nucleotide and amino acid changes associated with the different genotypes involved (4, 10 ) were probably not linked to major changes in virulence for mammalian hosts, and that all 3 variants might have contributed to human disease in the 2010 outbreak.
This increase may not be solely explained by genetic factors or population redistribution derived from migration phenomena, but also because of environmental factors linked to major changes in the quality of life, more prone to energy homeostasis imbalance and fat accumulation [ 7- 10].
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These developments have been linked to major societal changes such as the rising economic independence of women, the expansion of higher education, the declining influence of the church, and the spread of modern individualistic values (Blossfeld 1995; Cherlin 1992; Lesthaeghe 1983).
Its emergence 30 years ago was linked to major landscape change in the northeastern United States.
The adverts link to major gambling websites, including Bet365, Betfair and Paddy Power.
These changes are linked to a major change in causes of death.
None has led to major changes.
The major cause is linked to environmental changes and affects mainly the very poor populations [37, 38].
Heimhofer, U. et al. Timing of early Cretaceous angiosperm diversification and possible links to major paleoenvironmental change.
In fact, the small changes are linked to the big changes; the people making all those small decisions together make the major movements possible.
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