Sentence examples for linked to efficacy from inspiring English sources

Although lithium's low therapeutic index had the potential to elicit untoward effects during a 4-month survival study, we sought to duplicate exactly the dosing regimen used by Fornai et al. [1] because it showed unequivocal efficacy, and this efficacy was linked to efficacy in ALS patients.

Recombination is linked to efficacy of purifying selection in populations [ 38] and also within genomes.

Of note, the 80 125 % criterion is not directly linked to efficacy or safety.

Table 3 summarizes known genetic polymorphisms that are linked to efficacy and adverse reactions of drugs commonly used in LN.

We also agree with the authors that toxicity could be linked to efficacy; however, this has not been shown in early drug development (Postel-Vinay et al, 2009).

Suggestive of its potential pathogenic activity, significant decreases in seroreactivities to HERV-W envelope antigens, closely linked to efficacy of interferon-beta therapy were previously demonstrated [37] and recently, it has been reported that after one year therapy, natalizumab inhibits the plasma-membrane levels of the ENV protein in MS patients [38].

In addition, it has been suggested that the development of hypertension is linked to treatment efficacy.

"We have shown that this is the case for antipsychotic drugs some years ago but this is a major step-up, confirming that almost one-quarter of drugs investigated impact the microbiome," he said, adding that work is now needed to unpick how effects on the microbiome might be linked to the efficacy and side effects of drugs.

The results of this study show that in mice, where the protein binding rate is similar to the one in humans, cefditoren total t>MIC values of ≈35% were linked to therapeutic efficacy, and the required values decreased when animals were pre-immunized.

Furthermore, altered drug-metabolizing gene expressions are often linked to drug efficacy and safety issues.

All these parameters have been linked to reduce efficacy of chlorambucil monotherapy in the UK LRF CLL4 trial.