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Impaired processing of threat-related stimuli has also been previously linked to dysfunction of the amygdala in paranoid patients with schizophrenia [ 44].
Thus, like other neurodegenerative conditions, motor neuron disease has been linked to dysfunction of both the ubiquitin proteasomal and endosome/lysosome systems.
SZ has been linked to dysfunction of prefrontal cortical (PFC) g-aminobutyric acid (GABA) neurons and appears neurodevelopmental in nature [ 24- 28].
Both are linked to dysfunction of the platelets and the endothelium, the use of antiplatelet and anticoagulative medication, as well as anemia associated with chronic kidney disease and uremia (23).
Indeed, of the 31 genes that produce phenotypes linked to dysfunction of the motile cilia upon knockdown, we have demonstrated that at least 16 of these genes affect the length, beating or organization of motile cilia.
Many genes have been tested for their implication in the genetic susceptibility for schizophrenia over the last 2 decades; however no studies have found a single gene unambiguously linked to dysfunction leading to schizophrenia.
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This study provides initial evidence of a specific deficit for actively binding information in schizophrenia, which is linked to dysfunctions in the neural networks underlying attention, manipulation of information, and encoding strategies.
These data suggest that the role of Vav1 in thymic lymphomagenesis could be linked to dysfunctions in its direct downstream targets Rac1 and/or RhoA.
Chronic inflammation has been linked to endothelial dysfunction [ 9], and thus a decrease in endothelial dysfunction may be related to changes in inflammatory markers.
Interestingly, reduced adiponectin levels have been linked to endothelial dysfunction in humans (45), and adiponectin was shown, in animals, to improve endothelial dysfunction (46).
Electricity is another physical environmental factor linked to energy dysfunction.
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