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Interestingly, variations in the presence of SNAG-1 or SNAG-2 seem to be linked to duplication events, as in several instances SNAG domains are lost in some but not all of the paralogs.
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Gene expression divergence has also been linked to gene duplication.
The expansion of gene families in plants is most frequently linked to genome duplication events.
We also observe clear evidence of selection and adaptation to the environment directly linked to gene duplication.
The classic nuclear mitosis / cytokinesis checkpoint is absent in trypanosomes, where cytokinesis is linked to kinetoplast duplication and segregation [ 38].
Functional divergence of cysteine rich proteins (CRPs) has often been linked to gene duplication followed by positive selection acting to alter protein function [ 32]–[ 34].
For instance, the chicken pea comb phenotype was linked to a duplication near the first intron of SOX5 (Wright et al. 2009).
Unequal crossing over and gene conversion are often linked to tandem duplication, which results in arrays of similar regions of DNA.
The origin of Pol V, specific to angiosperms, from Pol IV, which is present in all land plants, is linked to the duplication of the gene encoding the largest subunit and the subsequent subneofunctionalization of the two paralogs (NRPD1 and NRPE1).
We have demonstrated that the expansion of the PE and PPE families is linked to the duplications of the ESAT-6 (esx) gene clusters.
Almost all aspects of the functional divergence of genes are in some way linked to gene duplications, which occur ubiquitously [ 49– 549.
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