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Expression of CD5, a molecule linked to attenuation of the TCR signal, was lower on DP and SP populations in the Gli2ΔN2 transgenic compared with WT littermates.
It is an amyloid deposition model in which selective p38αMAPK inhibition has been linked to attenuation of long-term potentiation (LTP) and cognitive dysfunction brought about by amyloid-beta (Aβ) stress.
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This attenuation has been linked to sensory attenuation during self-made acts [ 49], suggesting a failure of sensory attenuation in Parkinson's disease that rests on dopaminergic modulation of beta activity [ 5,50].
Although CXCL14 deficiency has been linked to the attenuation of obesity and brain control of behavior feeding (46).
This was linked to GABAB GIRK2 attenuation of synaptic plasticity as well as to reduced long term potentiation (LTP) and increased long term depression (LTD).
STAT-3 has also been linked to the attenuation of oxidative damage in different cellular compartments such as the mitochondrion [ 129].
The mechanism of the age-associated decline of BubR1 is linked to the attenuation of SIRT2, a member of the NAD+-dependent deacetylases and chronic, elevated p38α activity [ 55].
As lactacystin is a more potent proteasome inhibitor than MG-132, this suggests that its cardioprotective effects are more strongly linked to the attenuation of UPS-mediated induction of inflammatory pathways.
71, 114, 116 In addition to mitochondrial adaptations, activation of the SIRT1/PGC-1α axis is linked to the attenuation of age-related decline in skeletal muscle health in exercised rodents 49, 111, 113 via decreased oxidative stress and DNA damage, factors also implicated in the pathogenesis of many metabolic disorders associated with obesity.
SPOP has been linked to CUL3-mediated attenuation of signaling downstream of DAXX (death-associated protein 6) and hedgehog [26], [27].
Moreover, this altered mitochondrial condition is linked to a significant attenuation of the rate of development of oxidative biomarkers of aging.
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