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PPP2R2A deletions were recently linked to a subgroup of luminal breast carcinoma (BC) that exhibits poor survival.
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However, in glioma the 'methylator' subgroup was linked to a better prognosis [ 49].
They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C).
In an exploratory multivariate logistic regression analysis including the significant predictive markers from univariate analysis (biology-based tumor types, Ki67 labeling index, CK5/6 expression, grading, treatment arm; Table 2), the HR+/HER2+ subgroup was independently linked to a higher pCR rate (P = 0.046; compared to HR+/HER2-) while the HR-/HER2- group lost its predictive significance.
Defining the molecular pathologies that underpin these disorders will allow for more precise diagnostics to be developed, and might establish subgroups of a disorder consistently linked to a specific biomarker.
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We also used the sensitivity analyses described below to ascertain whether the heterogeneity identified in any meta-analysis was linked to any subgroups or individual articles by calculating the same heterogeneity statistics for each sensitivity analysis.
This is in accordance with our observation for this module, which shows that an induced module activity is linked to the subgroup with the worst outcome.
In all, 19 out of the 86 genes on our gene list were also linked to WNT subgroup medulloblastomas (Supplementary Table 2).
Our results support these ideas by indicating that the problems linked to those subgroups are associated also by trends of low satisfaction.
In order to find out if the variability at positions 70 and 91 was linked to subgroups of HCV-1b phylogenetic analysis of NS5A was performed, including the 13 strains from the present study as well as database sequences.
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CEO of Professional Science Editing for Scientists @ prosciediting.com