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Petry (1983) previously derived an effective migration rate for a neutral site linked to a selected site.
We have developed a likelihood method for estimating selection intensity and allele age from haplotype structure of multilocus SNPs closely linked to a selected mutant.
As the effective migration rate decays to zero if the neutral site is very closely linked to a selected site, this assumption will be violated.
On the other hand, several programs are available to simulate polymorphism data for a neutral locus linked to a selected site (e.g. Kim and Stephan, 2002; Pennings and Hermisson, 2006b; Spencer and Coop, 2004; Teshima and Innan, 2009), but they do not allow for population structure.
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I was present in both the selected and unselected pool and was thus likely linked to an inadvertently selected trait, such as sporulation capacity or spore viability.
Moreover, Faure et al. [ 49] proposed that diversifying selection helped to accelerate the evolution toward reciprocal monophyly at this specific gene in the Atlantic deep-sea vent mussels, suggesting that the SAHH gene may be indeed very sensitive to selection or linked to a potential positively selected gene.
A less severe version of this type of interference, that can decrease the efficacy of selection in sexual organisms, occurs when a locus under weak selection is tightly linked to a more strongly selected locus (i.e., Hill-Robertson Effect; [ 5, 6]).
For each encounter linked to a specimen, we selected a single ICD-9 code per individual specimen.
Consequently, six tetrapeptides that have high Dscore values are selected and linked to a spacer arm of [NH(CH2 6NH2] that is present on EAH Sepharose gel.
This was noted much earlier by Barton and Bengtsson (1986), who therefore considered a linear genome with an arbitrary number of selected loci linked to a focal neutral site.
In addition, we obtained an analytical formula for the effective migration rate experienced by a neutral or weakly beneficial site that is linked to an arbitrary number of selected loci.
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