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We are not aware of any previous observations that have linked side effects to any DMARD (including leflunomide) and anti-CCP antibody and rheumatoid factor positivity.
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Alternatively, an alternative source linking side effects to articles could be employed to supplement our existing analysis with side-effect data.
They clustered drugs according to their side-effect profiles and clustered side-effects according to the biological systems of their associated drugs (e.g., immune system) thereby linking side-effects and interaction patterns of drugs [4].
The targets can also be linked to side effects via protein-protein interactions by searching across ChEMBL, HPRD and SIDER in Chem2Bio2RDF.
And mainstream treatments for extreme morning sickness, like Zofran, are poorly studied and could be linked to side effects for the fetus, including heart defects.
Currently approved PPAR-γ ligands such as rosiglitazone have been linked to side effects, including fluid retention, heart failure, and other cardiovascular events, raising questions regarding their safety [54].
β-Arrestin and G protein-biased signaling has been linked to side effects of several GPCR drugs.
One possible mechanism linking mood/anxiety side effects to poor therapeutic response as judged by parents is that anxiety might be a shared trait between the child and his parents.
Overdosing has been linked to serious side effects, including infertility and coronary heart disease.
That drug was taken off the market late in 2000, less than 10 months after its approval, because it had been linked to serious side effects and a few deaths.
But it was never approved after being linked to psychiatric side effects, including suicide.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com