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One gene within the linked region caught his attention: WNT2, a member of a family of genes crucial to the early development of the central nervous system.
SCN9A is located on chromosome 2 within the linked region spanning 7.3 Mb, and showed a maximum logarithm of the odds score of 1.805 (Additional file 2: Table S3, Additional file 2: Figure S1).
The calcium-activated potassium channel gene (KCNN3; Mis602983) in in the vicinity of the FHM2 linked region on chromosome 1q21-23 region and proximal to a region linked to both FHM and typical migraine on chromosome 1q31 [15].
Moreover, this linked region encompasses the SNPH (Syntaphiliyn) gene.
The paternally linked region on chromosome 1 (1q23-1q24.2) was previously associated with autism.
A maternally linked region was observed on chromosome 5, with the peak at 5p13.1.
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Recent studies have demonstrated that the ACA X-linked region is X-linked not only among anoles (Gamble et al. 2014; Rovatsos et al. 2014a) but also across most phylogenetic lineages of iguanas (Pleurodonta; Rovatsos et al. 2014b).
The known X-linked region of ACA includes approximately 106 genes (National Center for Biotechnology Information) with orthologs linked to chromosome 15 of the chicken (Gallus gallus, GGA).
The cross-links maintain B-DNA geometry with small perturbations located at the cross-linked region.
Low nucleotide variation for the newly Y-linked region of its genome has been attributed to selective sweeps [57].
Because there is little or no hemizygous sex-linked region in Lepomis, there is little opportunity for deleterious interactions with autosomal loci.
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